| 1. | Nalidixic acid is effective primarily against gram-negative bacteria, with minor anti-gram-positive activity.
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| 2. | For example, WIN 18, 320 was nalidixic acid, the first quinolone antibiotic.
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| 3. | Quinolones ( including nalidixic acid and ciprofloxacin ) have this function.
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| 4. | They are very sensitive to ampicillin and resistant to kanamycin and nalidixic acid.
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| 5. | Most of the strains studied are resistant to ampicillin, kanamycin and nalidixic acid.
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| 6. | Other drugs can also be used, significant ones being chloramphenicol, streptomycin, and nalidixic acid.
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| 7. | They proved to be only marginal improvements over nalidixic acid.
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| 8. | The subunit A is selectively inactivated by antibiotics such as oxolinic and nalidixic acids.
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| 9. | It is resistant to cephalothin and nalidixic acid.
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| 10. | The first quinolone was nalidixic acid-introduced in 1962 for treatment of urinary tract infections in humans.
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